5-Amino-1MQ
5-Amino-1MQ research compound. Lyophilized powder, ≥99% purity by HPLC. For research use only.
About 5-Amino-1MQ
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule, not a peptide. It belongs to the quinolinium class of compounds and is used in research as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT).
Virexa Labs supplies 5-Amino-1MQ as a research compound for in-vitro laboratory research only – not for human or veterinary use.
The NNMT enzyme and how 5-Amino-1MQ acts on it
NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide. The enzyme is expressed mainly in the liver and in adipose tissue. Because nicotinamide is also a building block in the NAD+ salvage pathway, and SAM is the cell's main methyl donor, NNMT sits at a junction between NAD+ metabolism and methylation balance.
5-Amino-1MQ was designed as a small, cell-permeable compound that blocks NNMT activity – a tool for studying what happens to these pathways when NNMT is inhibited.
- Class: small-molecule quinolinium compound (not a peptide)
- Target: nicotinamide N-methyltransferase (NNMT)
- Pathways of interest: NAD+ salvage and SAM-dependent methylation
Research areas
5-Amino-1MQ has been investigated in cultured adipocytes and in rodent models of diet-induced obesity, where researchers look at adipocyte metabolism, lipid storage and cellular NAD+ levels. It is also used in skeletal-muscle and ageing models that explore the role of NNMT. These remain preclinical research questions.
Handling, dissolving and storage
Store the lyophilised powder at −20 °C, dry and protected from light; 2–8 °C is fine for short periods. Dissolve it in a solvent suited to your assay – sterile or bacteriostatic water is common – adding the solvent slowly and swirling rather than shaking. Keep solutions at 2–8 °C, use them within about four weeks and avoid repeated freeze–thaw cycles.
If you want to buy 5-Amino-1MQ for research: every batch is analysed by HPLC for ≥99% purity and by mass spectrometry for identity, with the COA shown on this page.
Frequently asked questions
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small-molecule quinolinium compound. We list it alongside our research peptides because it is used in the same area of metabolic research.
What is NNMT?
Nicotinamide N-methyltransferase, an enzyme that methylates nicotinamide using SAM as the methyl donor. 5-Amino-1MQ is studied as an NNMT inhibitor.
What purity does your 5-Amino-1MQ have?
≥99% by HPLC, with identity confirmed by mass spectrometry. The batch COA is linked on the product page.
How do I store 5-Amino-1MQ?
As a powder at −20 °C, dry and dark (2–8 °C short term). In solution at 2–8 °C, used within about four weeks, avoiding freeze–thaw cycles.
Is 5-Amino-1MQ suitable for human use?
No. It is sold strictly for in-vitro laboratory research and is not intended for human or veterinary use.