MOTS-C
MOTS-C research peptide. Lyophilized powder, ≥99% purity by HPLC. For research use only.
About MOTS-C
What is MOTS-C?
MOTS-C – often written MOTS-c, short for 'mitochondrial open reading frame of the 12S rRNA type-c' – is a 16-amino-acid peptide encoded in the mitochondrial genome rather than in nuclear DNA. First described in 2015, it belongs to the family of mitochondrial-derived peptides (MDPs), alongside humanin.
Virexa Labs supplies MOTS-C as a lyophilised research peptide for in-vitro laboratory research only – not for human or veterinary use.
Origin and mechanism
The MOTS-C sequence lies within the 12S rRNA region of mitochondrial DNA. In cell and animal models it has been linked to AMPK signalling – one of the cell's central energy sensors – and to the regulation of glucose and fatty-acid metabolism. In cultured cells under metabolic stress, MOTS-C has also been reported to move into the nucleus, which makes it a subject of research into communication between mitochondria and the nucleus.
- Length: 16 amino acids
- Origin: mitochondrial DNA, 12S rRNA region
- Family: mitochondrial-derived peptides (MDPs)
- Main pathway studied: AMPK signalling
Research areas
MOTS-C is studied in models of metabolic homeostasis, insulin sensitivity, skeletal-muscle metabolism and exercise physiology, as well as in ageing research. As one of the few known peptides encoded by mitochondrial DNA, it is also of interest to groups working on mitochondrial genetics and mitochondria-to-nucleus signalling. All of this is research in cell and animal models.
Handling, reconstitution and storage
Store the lyophilised vial at −20 °C, dry and protected from light; 2–8 °C is fine for short periods. Reconstitute with bacteriostatic water, added slowly along the inside of the vial, and swirl gently until dissolved – don't shake. Keep the solution at 2–8 °C, use it within about four weeks and avoid repeated freeze–thaw cycles.
Planning to buy MOTS-C for research? Every batch is tested by HPLC for ≥99% purity and by mass spectrometry for identity, and the COA is shown on this page.
Frequently asked questions
What is MOTS-C?
MOTS-C is a 16-amino-acid peptide encoded in the 12S rRNA region of mitochondrial DNA. It is studied in models of AMPK signalling and metabolic homeostasis.
Is MOTS-C the same as MOTS-c?
Yes. It is the same peptide; the scientific literature usually writes it with a lowercase 'c'.
What do I reconstitute MOTS-C with?
Usually bacteriostatic water. Add it slowly along the wall of the vial and swirl gently – don't shake.
How do I store MOTS-C?
Lyophilised at −20 °C, dry and dark (2–8 °C short term). Reconstituted at 2–8 °C, used within about four weeks, without repeated freezing and thawing.
Is MOTS-C suitable for human use?
No. Our MOTS-C is sold strictly for in-vitro laboratory research and is not intended for human or veterinary use.