CJC-1295
CJC-1295 research peptide. Lyophilized powder, ≥99% purity by HPLC. For research use only.
About CJC-1295 No DAC
What is CJC-1295 No DAC (Mod GRF 1-29)?
CJC-1295 No DAC, also known as Mod GRF 1-29 or modified GRF (1-29), is a synthetic GHRH analogue. It is based on the first 29 amino acids of growth-hormone-releasing hormone – the shortest fragment of GHRH that still retains full receptor activity.
Virexa Labs supplies CJC-1295 without DAC as a lyophilised research peptide for in-vitro laboratory research only. It is not intended for human or veterinary use.
Structure: four substitutions, no DAC
Native GRF (1-29) breaks down within minutes. Mod GRF 1-29 is a tetrasubstituted analogue: four amino acids are replaced (D-Ala at position 2, Gln at 8, Ala at 15 and Leu at 27) to make the peptide more resistant to enzymatic cleavage and oxidation, while preserving its affinity for the GHRH receptor.
The difference from CJC-1295 with DAC lies in the Drug Affinity Complex. The DAC version carries an extra lysine with a reactive group that binds covalently to albumin in the blood, greatly extending its half-life. The version without DAC lacks this, so it has a short half-life. In research this is relevant because a short-acting signal more closely resembles the natural, pulsatile release pattern of GHRH.
Research areas
CJC-1295 No DAC is studied in models of:
- GHRH receptor activation and cAMP signalling in pituitary cells
- pulsatile versus continuous stimulation of the GH axis
- comparisons between short-acting and long-acting GHRH analogues (with and without DAC)
- combination studies with ghrelin receptor agonists such as Ipamorelin
Handling, reconstitution and storage
Store lyophilised CJC-1295 No DAC at −20 °C, dry and dark (2–8 °C short term). Reconstitute with bacteriostatic water, added slowly along the vial wall, and swirl gently until dissolved – do not shake. Keep the solution at 2–8 °C, use within about 4 weeks and avoid freeze–thaw cycles.
Each batch is tested by HPLC (≥99% purity) and mass spectrometry; the COA is shown on this page. If you want to buy CJC-1295 No DAC for research, you can order it directly here.
Frequently asked questions
What is CJC-1295 No DAC?
CJC-1295 No DAC (Mod GRF 1-29) is a tetrasubstituted analogue of the first 29 amino acids of GHRH. It is a research peptide used in studies of the GHRH receptor.
What is the difference between CJC-1295 with and without DAC?
The DAC version contains a Drug Affinity Complex that binds to albumin, giving it a much longer half-life. The version without DAC (Mod GRF 1-29) has a short half-life and is studied as a model of pulsatile GHRH signalling.
What is the difference between CJC-1295 and Ipamorelin?
CJC-1295 is a GHRH analogue that acts on the GHRH receptor; Ipamorelin is a ghrelin receptor (GHS-R1a) agonist. They work through two different receptors.
How do I store and reconstitute CJC-1295 No DAC?
Lyophilised at −20 °C, dry and dark. Reconstitute with bacteriostatic water, swirl gently, store at 2–8 °C and use within about 4 weeks.
Is CJC-1295 No DAC suitable for human use?
No. This product is intended exclusively for in-vitro laboratory research and is not for human or veterinary use.