Tesamorelin

Tesamorelin research peptide. Lyophilized powder, ≥99% purity by HPLC. For research use only.

About Tesamorelin

What is Tesamorelin?

Tesamorelin is a synthetic analogue of growth-hormone-releasing hormone (GHRH), the hypothalamic peptide that signals the anterior pituitary to release growth hormone. It is supplied by Virexa Labs as a lyophilised research peptide for in-vitro laboratory research only – it is not intended for human or veterinary use.

Because Tesamorelin is built on the full-length GHRH sequence rather than a shortened fragment, it is a useful reference compound in studies that compare different GHRH analogues and their behaviour at the GHRH receptor.

Structure and mechanism

Tesamorelin comprises the complete 44-amino-acid sequence of human GHRH – GHRH(1-44) – with one key modification: a trans-3-hexenoyl group attached to the N-terminal tyrosine. Native GHRH is rapidly cleaved at its N-terminus by the enzyme dipeptidyl peptidase-4 (DPP-4). The hexenoyl group was introduced to make this end of the molecule more resistant to that enzymatic breakdown, while leaving the receptor-binding sequence intact.

Mechanistically, Tesamorelin acts as an agonist at the GHRH receptor (GHRH-R), a G-protein-coupled receptor on pituitary somatotroph cells. Receptor activation triggers the cAMP signalling cascade that is studied as the upstream step of GH synthesis and release.

Research areas

In the literature, Tesamorelin is studied in models of:

• GHRH receptor binding, activation and downstream cAMP signalling
• the regulation of the GH/IGF-1 axis in endocrine model systems
• peptide stability – comparing modified and unmodified GHRH sequences in enzymatic degradation assays
• comparative pharmacology alongside shorter GHRH analogues such as Mod GRF 1-29

Handling, reconstitution and storage

Store lyophilised Tesamorelin at −20 °C, dry and protected from light; 2–8 °C is acceptable for short periods. For reconstitution, bacteriostatic water is usually used: add it slowly along the inside wall of the vial and swirl gently until dissolved – do not shake. Keep the solution at 2–8 °C, use it within about 4 weeks and avoid repeated freeze–thaw cycles.

Every batch is tested by HPLC (≥99% purity) and mass spectrometry for identity, and the COA is shown on this page. If you want to buy Tesamorelin for research, you can order directly here – shipped from within the EU.

Frequently asked questions

What is Tesamorelin?

Tesamorelin is a synthetic GHRH(1-44) analogue with a trans-3-hexenoyl modification at the N-terminus. It is a research peptide used in in-vitro studies of the GHRH receptor and the GH axis.

How does Tesamorelin differ from CJC-1295?

Tesamorelin uses the full 44-amino-acid GHRH sequence with an N-terminal hexenoyl group. CJC-1295 (Mod GRF 1-29) is based on only the first 29 amino acids of GHRH, with four amino-acid substitutions for stability.

How do I store Tesamorelin?

Lyophilised: at −20 °C, dry and dark (2–8 °C short term). After reconstitution: at 2–8 °C, use within about 4 weeks and avoid freeze–thaw cycles.

What do I reconstitute Tesamorelin with?

Bacteriostatic water is usually used. Add it slowly along the vial wall and swirl gently; do not shake.

Is Tesamorelin suitable for human use?

No. Tesamorelin from Virexa Labs is intended exclusively for in-vitro laboratory research and is not for human or veterinary use.