Ipamorelin
Ipamorelin research peptide. Lyophilized powder, ≥99% purity by HPLC. For research use only.
About Ipamorelin
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide from the class of growth hormone secretagogues (GHS), often grouped with the growth-hormone-releasing peptides (GHRPs). It acts as an agonist at the ghrelin receptor, also known as the growth hormone secretagogue receptor type 1a (GHS-R1a). Its small size and well-defined sequence make Ipamorelin a common reference compound when researchers study the ghrelin receptor in isolation or compare different GH secretagogues.
Virexa Labs supplies Ipamorelin as a lyophilised research peptide for in-vitro laboratory research only. It is not intended for human or veterinary use.
Structure and mechanism
With just five amino acids (Aib-His-D-2-Nal-D-Phe-Lys-NH₂), Ipamorelin is one of the smallest compounds in its class. It contains non-natural building blocks, including aminoisobutyric acid and D-amino acids, which make the peptide more resistant to enzymatic degradation than a purely natural sequence.
Ipamorelin mimics the action of the endogenous hormone ghrelin at GHS-R1a. In pituitary models, activation of this receptor triggers a GH release signal through a different route from GHRH. What sets Ipamorelin apart in the literature is its selectivity: in animal studies it was found to have little effect on ACTH and cortisol compared with older GHRPs.
Research areas
Ipamorelin is studied in models of:
- ghrelin receptor (GHS-R1a) binding and signalling
- pulsatile GH release from pituitary cells
- receptor selectivity compared with older GHRPs such as GHRP-2 and GHRP-6
- interaction between the GHS-R and GHRH receptor pathways, for example in combination with CJC-1295
Handling, reconstitution and storage
Store lyophilised Ipamorelin at −20 °C, dry and away from light (2–8 °C short term). For reconstitution, bacteriostatic water is usually used: add it slowly along the vial wall and swirl gently, without shaking. Keep the solution at 2–8 °C, use within about 4 weeks and avoid freeze–thaw cycles.
Every batch is analysed by HPLC (≥99% purity) and mass spectrometry for identity; the COA is shown on this page. Looking to buy Ipamorelin for research? Order directly here, shipped from the EU.
Frequently asked questions
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide and a selective agonist of the ghrelin receptor (GHS-R1a). It is used as a research peptide in in-vitro studies of growth hormone secretagogues.
What is the difference between CJC-1295 and Ipamorelin?
CJC-1295 is a GHRH analogue and acts on the GHRH receptor. Ipamorelin is a ghrelin mimetic and acts on GHS-R1a. They target two different receptors, which is why they are often studied side by side or in combination.
How do I store Ipamorelin?
Lyophilised: at −20 °C, dry and dark (2–8 °C short term). Reconstituted: at 2–8 °C, use within about 4 weeks and avoid freeze–thaw cycles.
What do I reconstitute Ipamorelin with?
Usually with bacteriostatic water. Let it run slowly along the vial wall and swirl gently; do not shake.
Is Ipamorelin suitable for human use?
No. Ipamorelin from Virexa Labs is intended exclusively for in-vitro laboratory research and is not for human or veterinary use.