Kisspeptin
Kisspeptin research peptide. Lyophilized powder, ≥99% purity by HPLC. For research use only.
About Kisspeptin
What is Kisspeptin?
Kisspeptins are a family of peptides encoded by the KISS1 gene. The gene was first described in cancer research, which is why the longest form was originally named metastin. Today kisspeptin is mainly known as a key upstream regulator of the reproductive axis.
Virexa Labs supplies Kisspeptin-10, the shortest biologically active form, as a lyophilised research peptide. It is intended for in-vitro laboratory research only and is not for human or veterinary use.
Structure and mechanism
The KISS1 gene produces a precursor protein that is cleaved into several kisspeptins of different lengths, such as kisspeptin-54, -14, -13 and -10. They all share the same C-terminal sequence, which ends in an amidated Arg-Phe motif (RF-amide). Kisspeptin-10 consists of exactly these final ten amino acids – the minimal sequence needed to activate the receptor.
Kisspeptin acts on the KISS1 receptor (KISS1R), also known as GPR54, a G-protein-coupled receptor. In the hypothalamus this receptor is found on GnRH neurons. Activation of KISS1R is studied as an upstream step in the release of gonadotropin-releasing hormone (GnRH), which in turn regulates the release of LH and FSH from the pituitary – which is why kisspeptin is described as a gatekeeper of the hypothalamic-pituitary-gonadal (HPG) axis.
Research areas
Kisspeptin-10 is studied in models of:
- KISS1R (GPR54) binding and signalling
- GnRH neuron activity and GnRH pulsatility
- regulation of the HPG axis in endocrine model systems
- structure-activity relationships within the RF-amide peptide family
Handling, reconstitution and storage
Store lyophilised Kisspeptin at −20 °C, dry and protected from light (2–8 °C short term). For reconstitution, bacteriostatic water is usually used: add it slowly along the vial wall and swirl gently until dissolved – do not shake. Keep the solution at 2–8 °C, use within about 4 weeks and avoid freeze–thaw cycles.
Each batch is tested by HPLC (≥99% purity) and mass spectrometry for identity; the COA is shown on this page. If you want to buy Kisspeptin for research, you can order directly here.
Frequently asked questions
What is Kisspeptin?
Kisspeptin is a peptide encoded by the KISS1 gene that acts on the KISS1R (GPR54) receptor. It is studied as an upstream regulator of GnRH in the reproductive axis.
Which form of kisspeptin does Virexa Labs supply?
Kisspeptin-10: the C-terminal decapeptide shared by all kisspeptins and the shortest form that fully activates the receptor.
How do I store Kisspeptin?
Lyophilised: at −20 °C, dry and dark (2–8 °C short term). Reconstituted: at 2–8 °C, use within about 4 weeks and avoid freeze–thaw cycles.
What do I reconstitute Kisspeptin with?
Usually with bacteriostatic water, added slowly along the vial wall. Swirl gently; do not shake.
Is Kisspeptin suitable for human use?
No. Kisspeptin from Virexa Labs is intended exclusively for in-vitro laboratory research and is not for human or veterinary use.