SNAP-8
SNAP-8 research peptide. Lyophilized powder, ≥99% purity by HPLC. For research use only.
About SNAP-8
What is SNAP-8 (acetyl octapeptide-3)?
SNAP-8 is the common name of acetyl octapeptide-3, a synthetic peptide of eight amino acids with an acetylated N-terminus and an amidated C-terminus. It is an elongated analogue of acetyl hexapeptide-3: the hexapeptide sequence is extended by two amino acids, giving Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2. Acetylation and amidation remove the charged ends of the chain – a common modification that tends to make short synthetic peptides more resistant to breakdown by exopeptidases in experimental systems.
The name points to SNAP-25, the protein whose N-terminal region served as the template for this family of peptides.
The mechanism studied: the SNARE complex
The SNARE complex is a protein assembly that drives the fusion of vesicles with the cell membrane – a key step in the release of neurotransmitters such as acetylcholine at the neuromuscular junction. Its core components are SNAP-25, syntaxin and synaptobrevin (VAMP).
Because SNAP-8 mimics part of SNAP-25, it is studied as a peptide that may compete with SNAP-25 for its position in the complex and thereby modulate how the complex assembles. This makes SNAP-8 a tool compound in neuromuscular and cosmetic research models that examine vesicle release, mostly in vitro and often in direct comparison with acetyl hexapeptide-3.
Working with SNAP-8 in the lab
SNAP-8 is water-soluble and is usually reconstituted with bacteriostatic or sterile water. Add the solvent slowly along the inside wall of the vial and swirl gently until the powder has dissolved; avoid vigorous shaking. Let the vial reach room temperature before opening, so that no moisture condenses on the powder.
- Lyophilised: −20 °C, dry and protected from light; 2–8 °C for short periods.
- Reconstituted: 2–8 °C, use within about 4 weeks.
- Avoid repeated freeze–thaw cycles – aliquot the solution if needed.
Buy SNAP-8 research peptide
Want to buy SNAP-8? Our SNAP-8 comes as 10 mg of lyophilised powder. Every batch is analysed by HPLC and its identity confirmed by mass spectrometry; the certificate of analysis on this page documents the purity of the current batch.
SNAP-8 is sold for laboratory research use only – not for human or veterinary use, and not as a cosmetic ingredient.
Frequently asked questions
Is SNAP-8 the same as acetyl octapeptide-3?
Yes. SNAP-8 is the common name; acetyl octapeptide-3 is the systematic ingredient name of the same eight-amino-acid peptide.
What is the difference between SNAP-8 and acetyl hexapeptide-3?
SNAP-8 is an elongated analogue of acetyl hexapeptide-3: it carries two additional amino acids (Ala-Asp) at the C-terminal end. Both are derived from the N-terminal region of SNAP-25 and are studied as SNARE-complex modulating peptides.
What is the SNARE complex?
A protein complex of SNAP-25, syntaxin and synaptobrevin that mediates the fusion of vesicles with the cell membrane, for example during neurotransmitter release at the neuromuscular junction.
How should SNAP-8 be stored?
Lyophilised at −20 °C, dry and protected from light (2–8 °C short term). Once reconstituted, at 2–8 °C, used within about 4 weeks and without repeated freezing and thawing.
Can SNAP-8 be used in skincare or on humans?
No. This SNAP-8 is a research peptide for laboratory use only. It is not a cosmetic product and is not intended for human or veterinary use.