SS-31
SS-31 research peptide. Lyophilized powder, ≥99% purity by HPLC. For research use only.
About SS-31
What is SS-31 (elamipretide)?
SS-31, also known by its non-proprietary name elamipretide and the code MTP-131, is a synthetic, mitochondria-targeted tetrapeptide. It belongs to the Szeto-Schiller (SS) peptides, named after the researchers who developed them. Its sequence is D-Arg-Dmt-Lys-Phe-NH2, where Dmt stands for 2′,6′-dimethyltyrosine.
Virexa Labs supplies SS-31 as a lyophilised research peptide for in-vitro laboratory research only – not for human or veterinary use.
Structure and mechanism: binding to cardiolipin
SS-31 has an alternating aromatic–cationic structure and carries a net positive charge. This allows it to cross cell membranes and concentrate in the inner mitochondrial membrane, where it binds cardiolipin – a phospholipid found almost exclusively there and important for organising the electron transport chain. The D-arginine at the N-terminus and the amidated C-terminus make the peptide more resistant to enzymatic breakdown.
- Sequence: D-Arg-Dmt-Lys-Phe-NH2
- Synonyms: elamipretide, MTP-131, Szeto-Schiller peptide 31
- Target: cardiolipin in the inner mitochondrial membrane
Research areas
SS-31 is investigated in models of mitochondrial dysfunction, oxidative stress, ATP production and mitochondrial membrane integrity. Research groups use it in cardiac, skeletal-muscle, renal and neurodegeneration models and in ageing studies – often as a tool compound to test whether stabilising cardiolipin changes readouts such as mitochondrial respiration or reactive oxygen species production.
Elamipretide has also been evaluated in clinical trials by its developer. The SS-31 sold here is a research reagent.
Handling, reconstitution and storage
Store the lyophilised vial at −20 °C, dry and protected from light; 2–8 °C is fine for short periods. Reconstitute with bacteriostatic water, added slowly along the vial wall, and swirl gently – don't shake. Keep the solution at 2–8 °C, use it within about four weeks and avoid repeated freeze–thaw cycles.
If you want to buy SS-31 for research: every batch is tested by HPLC for ≥99% purity and by mass spectrometry for identity, and the COA is linked on this page.
Frequently asked questions
Is SS-31 the same as elamipretide?
Yes. Elamipretide is the non-proprietary name of SS-31; MTP-131 is another code used for the same tetrapeptide.
What is the sequence of SS-31?
D-Arg-Dmt-Lys-Phe-NH2: D-arginine, 2′,6′-dimethyltyrosine, lysine and phenylalanine, with an amidated C-terminus.
What purity does your SS-31 have?
≥99% by HPLC, with identity confirmed by mass spectrometry. The batch COA is shown on the product page.
How should SS-31 be stored?
Lyophilised at −20 °C, dry and dark (2–8 °C short term). Reconstituted at 2–8 °C, used within about four weeks, avoiding freeze–thaw cycles.
Is SS-31 suitable for human use?
No. Our SS-31 is sold strictly for in-vitro laboratory research and is not intended for human or veterinary use.